CROs
Predictable Enrollment. Confident Delivery.
Polus Health strengthens your trial performance with uniform, pre-validated candidate pipelines, reducing screen failures, improving forecast accuracy, and helping you deliver timelines sponsors can trust.
The Problem
You’re Responsible for Delivery, Even When the Problem Isn’t Yours.
Your study is active, but what works on paper starts to break down at the site level as performance varies and timelines become harder to maintain.
- Feasibility doesn’t equal enrollment
- Site variability slows timelines
- Rescue sites increase cost
- Diversity gaps add pressure
- You’re still held accountable
You’re expected to deliver the outcome. Even when you don’t control what drives it.
The Real Bottleneck
The Problem Isn’t Execution. It’s What You Don’t Control.
Site-level prescreening varies widely, and you inherit the variability that comes with it.
When unqualified candidates enter screening, performance diverges across sites, breaking feasibility assumptions and forcing reactive decisions.
By the time it’s visible, you’re already behind, and recovery means adding sites, increasing cost, or absorbing margin loss.
A New Way Forward
Take Control of What Enters Your Sites
Polus Health validates eligibility before candidates reach your sites, so you have visibility and consistency in what enters your study
You don’t change how your sites operate. You reduce the variability they introduce.
Predictable enrollment = predictable timelines. Polus is your enrollment insurance policy.
How It Works
How Polus Helps You Protect Your Timelines.
Step 1: Structured Intake
Candidate data, protocol criteria, and intake inputs are structured and standardized across your sites before screening begins.
Instead of relying on inconsistent site-level prescreening, every site starts from the same intake framework, creating a more controlled and repeatable front-end process.
This reduces variability at the source so feasibility projections better align with execution.
Step 2: Upstream Validation
Our AI and retinal specialists reduce screen-fails by up to 40%, improving cost per randomized candidate and eliminating false starts before they create downstream issues.
By removing the noise that forces sites into rescue mode, Polus helps your team spend less time in crisis management and more time keeping the study on track.
This creates cleaner enrollment inputs, fewer delays, and stronger delivery across your sites.
Step 3: Clean Handoff
Your sites receive a clear, standardized report of pre-validated candidates aligned to your protocol and sponsor expectations.
Each report includes:
- Verified candidate eligibility
- Protocol logic pathways
- Documentation ready for audit
- Flags for diversity targets
- Visit-ready candidate referrals
Everything is HIPAA and BAA compliant, IRB-approved, and fully traceable, supporting QA review and sponsor oversight.
This gives your team defensible enrollment inputs you can stand behind in sponsor conversations, governance meetings, and audits without scrambling to explain variability or delays after the fact.
Why Polus Health
What Changes When Enrollment Becomes Predictable
Enrollment Insurance
Lower screen-fail rates lead to more predictable LPI and LPO timelines, while reducing cost per randomized candidate by 15–25%.
Fewer Rescue Sites
Improve prescreening accuracy to reduce mid-study expansions and protect margins.
Repeat Sponsor Business
Deliver consistent performance across trials to strengthen sponsor trust and increase repeat work.
Stronger Bid Defenses
Give your team a clear recruitment differentiator with uniform prescreening, diversity-ready pipelines, and consistent SFR improvement.
Diversity Metrics Built In
Support FDA and EMA expectations with traceable screening and demographic data.
See How Your Enrollment Can Be Improved
Who We Are
Built By Retina Research Professionals
Polus Health was built by clinical research professionals who understand the pressure CROs face to deliver predictable timelines across diverse sites.
We work upstream of enrollment to validate eligibility, imaging, and prescreening inputs before they introduce downstream risk. The result is cleaner handoffs to sites, fewer surprises for sponsors, and greater confidence in delivery.
Polus operates as a neutral layer between sponsors and sites, strengthening execution without disrupting established workflows.
Therapeutic Areas
Expertise in the Trials You Are Running
Our team has worked across the same retina and imaging-driven trials you are running and supports them with deep expertise in protocol criteria, imaging, and eligibility logic.
Diabetic Macular Edema (DME)
Diabetic Retinopathy (DR)
- Proliferative Diabetic
- Retinopathy (PDR)
- Nonproliferative Diabetic
- Retinopathy (NPDR)
Age-related Macular Degeneration (AMD)
- Dry Age-related Macular Degeneration (Dry AMD)
- Wet Age-related Macular Degeneration (wAMD)
- Neovascular Age-related Macular Degeneration (nAMD)
- Geographic Atrophy (GA)
Inherited Retinal Disease
- Stargardt Disease
- Retinitis Pigmentosa (RP)
Retinal Vein Occlusion (RVO)
- Central Retinal Vein Occlusion (CRVO)
- Branch Retinal Vein Occlusion (BRVO)
- Hemi-Retinal Vein Occlusion (HRVO)
- Retinal Artery Occlusion (RAO)
Uveitis
- Panuveitis
- Anterior Uveitis
- Intermediate Uveitis
- Posterior Uveitis
The Polus Guarantee
Only Pay for Results.
We understand the operational and financial pressure clinics face with every trial. That’s why Polus Health operates on an outcomes-based model.
- No subscription fees
- No monthly minimums
- One-time admin startup fee
- Only billed for successful patient screenings / enrollments
It’s a simple, transparent model built on trust, results, and shared success. We only succeed when you do.
Get Started.
Pick a time that works for you. We’ll discuss your current enrollment challenges, identify where inefficiencies exist, and show you where we can help.
No preparation. No commitment. Just a simple conversation.